RTC-ImagingRadboud Imaging Center


Lianne Loeffen
Geert Grooteplein Zuid 10, 6525 GA Nijmegen
06 - 5000 8431

The Radboud Imaging Center provides the most up-to-date equipment and expertise for imaging research. The research facilities are organized in seven units: CLIC (Clinical Imaging Center, for clinical studies involved medical imaging and clinical imaging facilities), DCCN (Donders Center for Cognitive Neuroimaging), Radboud AI for Health (for deep learning automated image analysis HPC with 100 GPUs), PRIME (Preclinical Imaging Center, for animal imaging), RTM (Radboud Translational Medicine) a cyclotron facility for the GMP manufacturing of radiotracers, MIC (Microscopic Imaging Center for advanced microscopy) and the Radboud-3D lab (for advanced 3D imaging applications). The Radboud Imaging Center provides services for Dutch and international research institutes as well as industry.

The Radboud Imaging Center provides frontline facilities and expertise for noninvasive imaging in patients, animal models and biological samples for biomedical research, as well as IT infrastructure and expertise on handling and processing medical image data. The following facilities are provided:
• CLIC provides noninvasive patient imaging with MRI (1.5 - 7T), CT (up to 320-slice), PET/CT, US, SPECT/CT, and fluorescence imaging. The cyclotron of RTM and GMP facilities for tracer preparation provide a vast spectrum of customized probes for radionuclide imaging. Apart from standard morphological imaging techniques, various novel functional techniques are available with MR, CT, PET and US, some of which are unique for the Netherlands and have been developed in close cooperation with industry.
• DCCN provides morphologic and functional 3 – 7 T MR imaging of the brain, MR morphometry, fMRI, connectivity analysis using resting state fMRI and diffusion weighed imaging.
• Radboud AI for health, provides a high performance computing cluster with over 100 GPUs and a software platform to support image-based clinical and preclinical studies by providing IT infrastructure for data storage and an effective viewing and quantitative evaluation environment with modules for algorithm development and high-end automation to facilitate evaluation of very large imaging databases.
• RTM provides a 11 MeV cyclotron for production of radionuclide and GMP facilities for production of tracers for PET imaging.
• PRIME is an official node in the Euro-Bioimaging network and a Dutch technology hotel. It provides advanced equipment for small animal and tissue imaging with 11.7 T MRI, 7 T MRI, HRMAS, microPET/CT, microSPECT/CT, high frequency ultrasound (20,40 and 55 MHz), fluorescence imaging, bioluminescence imaging, multi-photon fluorescence and non-linear microscopy and photoacoustic imaging.
• MIC provides facilities for microscopic imaging of biological samples using Advanced Microscopy, such as CLSM, TIRF, FCS, FLIM, SEM, TEM, AFM, single-particle tracking, and high-content imaging.
• The Radboud-3D lab provides facilities for Cone Beam CT, 3D stereo-photogrammetry, Intra-oralscanning, 3D printing and Virtual and Augmented reality.
The infrastructure of the Radboud Imaging Center is continuously being updated to incorporate the newest developments in the field. In the near future the Clinical Imaging Center aims to acquire next-generation equipment for simultaneous PET-MRI, as well as an MR-Linac for radiotherapy under real-time MRI guidance. PRIME will acquire equipment for tomographic fluorescence imaging and micro-endoscopic imaging in mice and rats, while the Microscopic Imaging Center will extend its armamentarium with equipment for Multimodal Molecular Imaging. The 7T MRI facilities are shared with the University of Essen; renewal of that clinical/research system is planned for 2021. MIC is currently implementing light-sheet and super-resolution microscopy (STORM, structured illumination microscopy) and has recently acquired a unique 3D (cryo) correlative light electron microscopy workflow.

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